This paper discusses the problem of detecting network anomalies caused by computer attacks in industrial Internet of Things networks. To detect anomalies, a new method has been developed using the technology of hierarchical temporary memory, which is based on the innovative neocortex model. An experimental study of the developed anomaly detection method based on the HTM model demonstrated the superiority of the developed solution over the LSTM-based analogue. The developed prototype of the anomaly detection system provides continuous online unsupervised learning, takes into account the current network context, and also applies the accumulated experience by supporting the memory mechanism