In order to guarantee effective information security of an organization, a systematic and comprehensive approach is necessary. One of the most effective tools for obtaining an independent and objective assessment of organizations’ security against information security risks and threats and evaluating the level of organization IS provision is the internal information security audit. Nowadays, more and more additional requirements are imposed to the methods of ensuring and conducting IS audit. Having analyzed the scientific literature, training manuals and articles in the field of information security, a method based on the risk-oriented approach is developed. The risk management theory and the internal audit methodology built on its basis should become the tools for conducting the audit. Information security audit based on the risk-oriented approach will make it possible to assess the security of the organization, identify risks, create and (or) adjust the plan of measures to minimize them, improve the interaction of departments responsible for control and risk management